John Boland Hughes, 75, died August 21, 2021, of Alzheimer's disease. He was the husband of Rosalie Scott Day Hughes. He was born in Philadelphia, PA to the late Dr. Joseph F. and Anne Opie Hughes. John was particularly proud to be the grandson of Dr. Eugene Opie, a distinguished pathologist at Rockefeller University. John was a graduate of the Haverford School, Yale University 1967, and Harvard Medical School 1971. He served, as he always liked to say, on "the Eastern Front" during the Viet Nam War, as a physician in Washington D.C. Stories abounded of famous statesmen brought to their knees with gratitude for the thoroughness of Dr. Hughes' exams; he often included extraneous and unpopular procedures to prove how much their good health mattered to their country. John and Rosalie lived on Manhattan's Upper West Side for over forty years and retired to Annisquam, where they had long spent summers, in 2017. The adjustment was a bit rough with no superintendent to call when something broke, but, a few years in, found they could fire up the woodstove without filling the entire house with smoke. Until he concluded that medicine involved too many patients, John worked as a physician in New York City and for Pan Am Airlines which offered stand-by flights around the world as a perk. He made the transition to medical technology which allowed him to travel widely, especially in Eastern Europe and particularly in Russia, looking for advances in the field. He taught himself Russian listening to Pimsleur tapes while jogging around the Reservoir in Central Park. A lot of people thought he was a spy, but we're pretty sure he was not. John loved to travel, and until the very end was planning his next trip: Argentina. He and Rosalie traveled around the world for six months on their honeymoon, funded by a six week locum in Saudi Arabia where John treated his first tarantula bite and Rosalie got pinched in bazaars. In addition to his wife, Rosalie, to whom he was married for forty-four years, John is survived by their three daughters, Lindsay Keith Hughes Wands and her husband Michael of Needham, Mary Welby Scott Hughes Lamb and her husband Sean T. of New York, New York, and Elizabeth Day Hughes of Washington Heights, New York, his siblings, Dr. William Hughes and his wife Ann Compton of Washington D.C., Thomas Hughes and his wife Carolyn of The Woodlands, Texas, Sally H. Thompson and her husband Peter of Newtown, Pa. and, Dr. David Hughes and his wife Tricia of Lancaster, Pa.; four grandchildren, Maisie, James and Andrew Wands, and Elizabeth Lamb, twenty three nieces and nephews and all their children. John was predeceased by siblings Lynne Huhn Floyd, Joseph Hughes, Dr. James E. O. Hughes. His memorial service will be held at Annisquam Village Church 820 Washington Street, Gloucester on Thursday August 26, 2021 at 11 am. Relatives and close friends are invited to attend, respecting COVID rules. Arrangements by the Campbell Funeral Home 61 Middle Street Gloucester. Contributions may be made in John's name to Young Adult Institute, 220 E 42nd St, 8th Floor, New York, NY 10017, which has been instrumental in his daughter Eliza's care.